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Dr. Todd Ponsky

Pediatric Surgery · View profile →

Appendectomy for Therapy-Refractory Ulcerative Colitis

Video Published 2019-12-27 Updated 2024-02-10

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Topic Overview

Prospective multicenter study (Journal of Crohn's and Colitis, Feb 2019) showed appendectomy achieved sustained symptomatic improvement in 30% of therapy-refractory ulcerative colitis patients, with pathologic improvement in 50% and complete endoscopic remission in 17%.

Key Takeaways

  • Appendectomy achieved sustained symptomatic improvement in 30% of patients with therapy-refractory ulcerative colitis
  • Pathologic improvement occurred in 50% of patients following appendix removal
  • Complete endoscopic remission was documented in 17% of patients post-appendectomy
  • Prospective multicenter data supports appendectomy as a treatment option when medical therapy fails in UC
  • Consider appendectomy before escalating to colectomy in select refractory pediatric UC cases

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