Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity
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- - Liver-derived extracellular vesicle signals drop sharply after vertical sleeve gastrectomy in adolescents with obesity - Adipose tissue-derived vesicle cargo remains unchanged post-bariatric surgery, showing organ-specific responses - Liver vesicle signals correlate strongly with BMI, leptin, and insulin resistance months after surgery - Organ-to-organ communication via extracellular vesicles may drive metabolic improvements seen after bariatric surgery - Different organs use distinct vesicle signaling patterns to coordinate metabolic changes following weight loss surgery
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Did you know that your organs can message each other after bariatric surgery? I am Lizzie Lee from Cincinnati Children's and this is an article you should know about. This is a new study in teens undergoing sleeve gastroxamine. Researchers looked at tiny messengers called small etchocelio vesicles, little molecular packages released by organs, what happens after surgery? The liver dramatically quites down its signals. Liver enriched mRNA in these vesicles drops sharply, while antiposterrized cargo remains unchanged. What's interesting is that liver derived vesicles signals strongly correlate with BMI, left in, and resistant months after surgery. So the big takeaway? After a vertical sleeve gastroxamine surgery, the liver and fat tissue talk to each other in totally different ways, and that crosstalk may drive the metabolic improvements that we see clinically. Let us know what you think in the comments below and stay tuned for more articles that you should know about.