Real-world Multi-institutional Data From the Midwest Pediatric Surgery Consortium (MWPSC) to Assess the Effect of Delayed Kasai Procedure on Biliary Drainage in Patients With Biliary Atresia

Topic overview

Key takeaways

• Early Kasai portoenterostomy timing remains inconsistent across US institutions despite known survival benefits in biliary atresia patients.
• Jaundice clearance at 3 months post-Kasai is a validated predictor of transplant-free survival in infants with biliary atresia.
• Multi-institutional data reveals significant variability in both hyperbilirubinemia workup initiation and surgical timing for Kasai procedures.
• Delayed Kasai procedure timing negatively impacts biliary drainage success and long-term transplant-free outcomes.
• Standardizing early referral pathways and expediting Kasai timing could improve jaundice clearance rates and reduce transplant need.

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