Is It Time to Introduce Ex-Situ Normothermic Machine Perfusion in Paediatric Liver Transplantation?
Topic overview
This study investigates whether normothermic machine perfusion technology can be safely adapted for pediatric liver transplantation by examining left lateral segment grafts during extended perfusion. The research addresses current barriers including technical challenges with smaller grafts and concerns about portal hyperperfusion injury that have prevented use in children.
Key takeaways
- Normothermic machine perfusion is not yet used in pediatric liver transplants due to technical challenges with smaller grafts.
- Portal hyperperfusion injury is a key risk when perfusing left lateral segment grafts used in pediatric recipients.
- This study evaluates whether long-term NMP can safely preserve smaller liver grafts for children.
- Haemodynamic monitoring and histological assessment are critical to adapting NMP technology for pediatric use.
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How to cite: GlobalCastMD. Is It Time to Introduce Ex-Situ Normothermic Machine Perfusion in Paediatric Liver Transplantation?. GlobalCastMD Medical Library. 2025-02-04. https://dev.library.globalcastmd.com/article/9744?via_space=staycurrentmd
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