Long-term parenteral nutrition and delayed establishment of enteral nutrition in extremely low birth weight infants with high enterostomy site is associated with prolonged cholestasis
Topic overview
This retrospective study examines cholestatic liver damage in extremely low birth weight infants after enterostomy. Prolonged parenteral nutrition and delayed enteral feeding, particularly in infants with higher enterostomy sites and lower birth weights, significantly increased cholestasis risk and reduced survival rates.
Key takeaways
- Prolonged cholestasis in ELBWIs with enterostomy is associated with significantly lower survival (52.4% vs 88.9%).
- Higher enterostomy site (shorter residual bowel length) correlates with prolonged cholestasis and delayed enteral feeding.
- Duration of parenteral nutrition is an independent risk factor for prolonged cholestasis in ELBWIs post-enterostomy.
- Early establishment of enteral feeding (>100 ml/kg/day) may help prevent prolonged cholestatic liver damage.
- Lower birth weight (<600g) increases risk of cholestatic complications following neonatal enterostomy.
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How to cite: GlobalCastMD. Long-term parenteral nutrition and delayed establishment of enteral nutrition in extremely low birth weight infants with high enterostomy site is associated with prolonged cholestasis. GlobalCastMD Medical Library. 2024-12-20. https://dev.library.globalcastmd.com/article/9554?via_space=staycurrentmd
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