Global Prevalence of Duodenal Atresia in Trisomy 21: A Systematic Review and Meta-Analysis
Topic overview
This systematic review and meta-analysis examines the global prevalence of duodenal atresia in Down syndrome patients, finding an overall rate of 3.0% with significant regional variation. The study analyzes 18 studies across multiple regions, revealing higher prevalence in the Middle East (6.0%) and lower rates in Latin America and Canada (1.0%), with no significant gender differences.
Key takeaways
- Duodenal atresia affects 3% of Down syndrome patients globally, with significant regional variation (1-6% prevalence).
- Middle East shows highest prevalence (6%), while Latin America, India, and Canada report lowest rates (1%).
- Gender does not impact duodenal atresia prevalence in Down syndrome—both males and females show 3% incidence.
- High-quality studies report lower prevalence (2%) compared to moderate-quality studies (4%), suggesting methodological factors.
- Regional screening protocols for duodenal atresia in Down syndrome patients should account for geographic variation in prevalence.
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How to cite: GlobalCastMD. Global Prevalence of Duodenal Atresia in Trisomy 21: A Systematic Review and Meta-Analysis. GlobalCastMD Medical Library. 2024-12-11. https://dev.library.globalcastmd.com/article/9519?via_space=staycurrentmd
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