Yes-associated protein is dysregulated in human congenital diaphragmatic hernia patients during mid and end gestation
Topic overview
This study examines Yes-associated protein (YAP) dysregulation in human CDH fetuses, finding elevated levels of inactive phosphorylated YAP throughout gestation. The research suggests this YAP inactivation disrupts normal lung development and cellular differentiation, providing molecular insights into CDH pathogenesis and potential therapeutic targets.
Key takeaways
- YAP protein is dysregulated in CDH fetal lungs, with increased levels of inactive phosphorylated YAP (p-YAP) compared to controls.
- Elevated p-YAP in CDH suggests impaired YAP signaling may disrupt normal lung development during mid and end gestation.
- CDH lungs show altered cellular differentiation with more SPC-positive cells and fewer HOPX-positive cells at end-gestation.
- YAP dysregulation may be a key molecular mechanism underlying abnormal lung development in congenital diaphragmatic hernia.
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How to cite: GlobalCastMD. Yes-associated protein is dysregulated in human congenital diaphragmatic hernia patients during mid and end gestation. GlobalCastMD Medical Library. 2024-12-02. https://dev.library.globalcastmd.com/article/9474?via_space=staycurrentmd
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