Characteristics, progression, management, and outcomes of NEC: a retrospective cohort study
Topic overview
This retrospective study of 208 preterm infants with necrotizing enterocolitis (NEC) found that 32% progressed from medical to surgical NEC within a median of 2.5 days, while 16% presented with surgical disease from onset. Surgical NEC cases had significantly worse outcomes including longer hospital stays, increased morbidity, and higher mortality compared to medical NEC alone.
Key takeaways
- 52% of preterm NEC cases remain medical, 32% progress to surgical NEC, and 16% present as surgical NEC from onset.
- Lower gestational age, birth weight, and postnatal age at diagnosis are inversely associated with progression to surgical NEC.
- Median time from medical NEC to surgical NEC progression is 2.5 days, creating a narrow window for intervention.
- Surgical NEC patients require significantly longer antibiotics, respiratory support, and hospital stays compared to medical NEC.
- Surgical NEC is associated with higher rates of recurrent NEC, bronchopulmonary dysplasia, and mortality in preterm infants.
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How to cite: GlobalCastMD. Characteristics, progression, management, and outcomes of NEC: a retrospective cohort study. GlobalCastMD Medical Library. 2024-11-29. https://dev.library.globalcastmd.com/article/9472?via_space=staycurrentmd
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