Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997–2021
Topic overview
This Danish nationwide study tracked 1.5 million live births over 25 years, finding stable omphalocele prevalence at approximately 1 per 10,000 infants. Notably, over half of affected infants presented with additional major malformations and 17% had diagnosed syndromes, highlighting the complex care needs for this population.
Key takeaways
- Omphalocele birth prevalence in Denmark remained stable at 0.98 per 10,000 live births over 25 years (1997-2021).
- Over half (53.7%) of liveborn infants with omphalocele had one or more co-occurring major malformations.
- An additional 17% of omphalocele cases were associated with a diagnosed syndrome, totaling 70.7% with complex presentations.
- Co-occurring malformations are the primary prognostic factor affecting morbidity and mortality in omphalocele patients.
- The high rate of complex cases has significant implications for long-term multidisciplinary healthcare planning and resource allocation.
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How to cite: GlobalCastMD. Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997–2021. GlobalCastMD Medical Library. 2024-11-22. https://dev.library.globalcastmd.com/article/9448?via_space=staycurrentmd
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