Increased risk of clinically relevant neurodevelopmental disorders in survivors of congenital diaphragmatic hernia: a population-based study
Topic overview
This Swedish population-based study of 641 CDH survivors found significantly elevated risks for neurodevelopmental disorders compared to controls, including 2.2-fold increased risk for any ND and 10.6-fold increased risk for intellectual disability. The findings highlight the importance of long-term neurodevelopmental surveillance in CDH survivors beyond the neonatal period.
Key takeaways
- CDH survivors show 2.2× higher risk of any neurodevelopmental disorder compared to general population (11.5% vs 5.6%, p<0.001).
- Intellectual disability risk is dramatically elevated in CDH survivors: 10.6× higher than controls (6.6% vs 0.7%, p<0.001).
- Autism spectrum disorder incidence nearly doubles in CDH survivors: 3.9% vs 2.1% in controls (1.9× risk, p=0.011).
- Neurodevelopmental sequelae persist as the most common long-term morbidity in CDH, warranting systematic developmental surveillance.
- Population-based data confirms clinically significant ND risk in CDH independent of screening bias—counsel families accordingly.
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How to cite: GlobalCastMD. Increased risk of clinically relevant neurodevelopmental disorders in survivors of congenital diaphragmatic hernia: a population-based study. GlobalCastMD Medical Library. 2024-11-11. https://dev.library.globalcastmd.com/article/9417?via_space=staycurrentmd
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