Angiopoietin-1 attenuates lipopolysaccharide-induced endotoxemia in a Hirschsprung’s disease murine model by improving intestinal vascular integrity: implications for treating postoperative Hirschsprung-associated enterocolitis
Topic overview
This preclinical study demonstrates that angiopoietin-1 (Ang1) reduces LPS-induced intestinal inflammation in a Hirschsprung disease mouse model by strengthening vascular barrier integrity and downregulating pro-inflammatory genes. The findings suggest Ang1 may offer a therapeutic approach for preventing or treating Hirschsprung-associated enterocolitis, a serious postoperative complication.
Key takeaways
- Angiopoietin-1 pretreatment significantly reduced LPS-induced intestinal inflammation in Hirschsprung's disease mice.
- Ang1 downregulated pro-inflammatory markers (IL-1β, SELE, VEGFA, Ang2) in normoganglionic ileum after endotoxin challenge.
- Ang1 improved intestinal vascular barrier integrity by increasing phospho-TIE2 and VE-cadherin expression.
- Hirschsprung mice showed heightened inflammatory response to LPS compared to wild-type, suggesting baseline vascular vulnerability.
- Ang1 may offer therapeutic potential for preventing or treating Hirschsprung-associated enterocolitis by stabilizing endothelial barriers.
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How to cite: GlobalCastMD. Angiopoietin-1 attenuates lipopolysaccharide-induced endotoxemia in a Hirschsprung’s disease murine model by improving intestinal vascular integrity: implications for treating postoperative Hirschsprung-associated enterocolitis. GlobalCastMD Medical Library. 2024-10-28. https://dev.library.globalcastmd.com/article/9354?via_space=staycurrentmd
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