Enhancement of enteric neural stem cell neurogenesis by glial cell-derived neurotrophic factor in experimental Hirschsprung’s disease
Topic overview
This study demonstrates that glial cell-derived neurotrophic factor (GDNF) significantly enhances the neurogenic potential of enteric neural crest cells from a Hirschsprung's disease mouse model. GDNF treatment increased neurosphere size and promoted differentiation of both neurons and glial cells, offering a promising strategy to optimize stem cell-based therapies for this congenital disorder.
Key takeaways
- GDNF supplementation increases neurosphere size and Sox10+ enteric neural crest cell density in Ednrb−/− HSCR model
- GDNF enhances differentiation of both TUJ1+ neurons and S100+ glial cells from HSCR-derived enteric stem cells
- Optimizing culture conditions with GDNF may improve efficacy of stem cell therapy for Hirschsprung's disease
- Ednrb knockout mouse model demonstrates that growth factor modification can enhance neurogenic potential of deficient ENCCs
Keywords
Hashtags
Full article text
Full article text not available for this entry
How to cite: GlobalCastMD. Enhancement of enteric neural stem cell neurogenesis by glial cell-derived neurotrophic factor in experimental Hirschsprung’s disease. GlobalCastMD Medical Library. 2024-10-26. https://dev.library.globalcastmd.com/article/9346?via_space=staycurrentmd
Comments