Surgery for hepatoblastoma in children with trisomy 18: a monocentric study
Topic overview
This monocentric study examines surgical outcomes for seven children with trisomy 18 and hepatoblastoma who underwent multidisciplinary treatment including chemotherapy and complete tumor resection. All patients achieved recurrence-free survival with acceptable perioperative complications, suggesting that children with trisomy 18 and stable cardiopulmonary status may benefit from active oncologic treatment for hepatoblastoma.
Key takeaways
- Children with trisomy 18 and hepatoblastoma can achieve complete surgical resection with multidisciplinary treatment when cardiopulmonary status is stable.
- Neoadjuvant chemotherapy effectively reduced tumor size in 3/7 cases, facilitating complete resection across PRETEXT I-III classifications.
- All seven trisomy 18 patients who underwent multidisciplinary treatment remained recurrence-free (follow-up: 3 months to 11 years).
- Perioperative complications were manageable: one circulatory failure case and two bile leakage cases among seven surgical patients.
- Active treatment paradigm shift: trisomy 18 patients with stable cardiopulmonary function are now viable candidates for hepatoblastoma surgery.
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How to cite: GlobalCastMD. Surgery for hepatoblastoma in children with trisomy 18: a monocentric study. GlobalCastMD Medical Library. 2024-08-14. https://dev.library.globalcastmd.com/article/9000?via_space=staycurrentmd
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