Bile lakes in patients with biliary atresia who presented with jaundice-free native liver survival indicating the risk of subsequent liver transplantation due to various factors

Topic overview

Key takeaways

• Bile lakes are the strongest predictor of subsequent liver transplantation in BA patients with jaundice-free survival at 1 year post-PE.
• Bile lakes increase risk not only through cholangitis but also via GI hemorrhage and hepatopulmonary syndrome complications.
• Risk score combining bile lake presence and total bile acids (2.38×BL + 0.00466×TBA) predicts transplant need with 0.83 AUC.
• Among BA patients jaundice-free at 1 year, bile lake status significantly stratifies native liver survival outcomes.
• Early bile lake detection enables targeted monitoring for multi-system complications requiring transplant evaluation.

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