Comparison and clinical analysis of antibiotics and endoscopic injection for vesicoureteral reflux in children
Topic overview
This retrospective study of 52 children with primary VUR compared antibiotic prophylaxis versus endoscopic dextranomer/hyaluronic acid injection. Endoscopic treatment achieved higher radiological resolution rates (57.4% vs 36.1%, p=0.048) with minimal complications, supporting its use in children with renal scarring or collecting system dilation.
Key takeaways
- Endoscopic dextranomer/hyaluronic acid injection achieved 64.8% overall success rate for pediatric VUR versus 36.1% resolution with antibiotics alone.
- Endoscopic injection had short operative time (36 min) and hospital stay (2.3 days) with no postoperative complications in this cohort.
- Renal scarring on DMSA scan (86.9% injection group vs 50% antibiotic group) and hydronephrosis on ultrasound are key indicators for endoscopic treatment.
- Two of 30 patients required repeat injection to achieve VUR resolution, suggesting initial failure rate of approximately 7%.
- Antibiotic prophylaxis remains appropriate first-line therapy; endoscopic injection is indicated for persistent reflux with renal changes.
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How to cite: GlobalCastMD. Comparison and clinical analysis of antibiotics and endoscopic injection for vesicoureteral reflux in children. GlobalCastMD Medical Library. 2024-07-12. https://dev.library.globalcastmd.com/article/8837?via_space=staycurrentmd
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