Treatment abandonment in children with Wilms tumor at a national referral hospital in Uganda
Topic overview
This Ugandan cohort study found that 45% of children with Wilms tumor abandoned treatment before completing neoadjuvant chemotherapy and surgery, with abandonment strongly associated with poor chemotherapy response and tumor size exceeding 25 cm. The findings highlight critical barriers to pediatric cancer care completion in resource-limited settings.
Key takeaways
- 86% of Wilms tumor patients in Uganda started chemotherapy, but only 55% completed treatment through surgery—indicating high abandonment rates.
- Treatment abandonment was significantly associated with poor chemotherapy response (OR 4.70) and tumor size >25 cm (OR 2.67).
- 71% of patients presented with stage III or higher disease, suggesting late diagnosis contributes to poor outcomes and treatment discontinuation.
- Families are more likely to abandon care during neoadjuvant therapy when tumors show poor response, highlighting need for early intervention strategies.
- Addressing barriers to treatment completion requires understanding both clinical factors (tumor biology, response) and socioeconomic factors in resource-limited settings.
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How to cite: GlobalCastMD. Treatment abandonment in children with Wilms tumor at a national referral hospital in Uganda. GlobalCastMD Medical Library. 2024-06-27. https://dev.library.globalcastmd.com/article/8778?via_space=staycurrentmd
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