The systemic immune-inflammation index at kasai portoenterostomy: related to clinical outcomes
Topic overview
This retrospective study of 168 biliary atresia patients demonstrates that preoperative Systemic Immune-Inflammation Index (SII) is a superior predictor of 24-month native liver survival after Kasai portoenterostomy. An SII threshold below 140.09 showed 90% sensitivity and 94% specificity for predicting favorable outcomes.
Key takeaways
- Systemic Immune-Inflammation Index (SII) <140.09 predicts 24-month native liver survival after Kasai with 90% sensitivity and 94% specificity.
- SII outperforms traditional markers (GGT, lymphocyte count, liver fibrosis grade) in predicting biliary atresia outcomes post-Kasai portoenterostomy.
- Patients with SII ≥140.09 have significantly lower rates of jaundice clearance (47% vs 75%) and liver function recovery compared to SII <140.09.
- Preoperative malnutrition, elevated GGT, low lymphocyte count, high SII, and advanced liver fibrosis independently predict poor native liver survival.
- SII is a simple, economical routine hematological marker that can guide prognostication and counseling for biliary atresia patients undergoing Kasai.
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How to cite: GlobalCastMD. The systemic immune-inflammation index at kasai portoenterostomy: related to clinical outcomes. GlobalCastMD Medical Library. 2024-06-08. https://dev.library.globalcastmd.com/article/8715?via_space=staycurrentmd
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