Utility of thiol/disulphide homeostasis as a biomarker for acute appendicitis: a systematic review and meta-analysis
Topic overview
This systematic review and meta-analysis of 11 studies (926 subjects) evaluates thiol/disulfide homeostasis as a potential biomarker for acute appendicitis. Results show significantly elevated oxidative stress markers in appendicitis patients versus controls, with lower total thiol levels distinguishing complicated from uncomplicated cases, though methodological limitations warrant further validation studies.
Key takeaways
- Thiol/disulfide homeostasis parameters show significantly increased oxidative stress in acute appendicitis versus healthy controls.
- Complicated appendicitis demonstrates lower total thiol levels compared to uncomplicated cases, suggesting potential prognostic utility.
- Meta-analysis of 926 subjects validates TDH as a measurable biomarker reflecting oxidative stress burden in acute appendicitis.
- Methodological limitations in 5/11 studies indicate need for larger prospective trials before clinical implementation of TDH testing.
- TDH parameters (native/total thiol, disulfide ratios) may complement traditional diagnostics but require validation in powered studies.
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How to cite: GlobalCastMD. Utility of thiol/disulphide homeostasis as a biomarker for acute appendicitis: a systematic review and meta-analysis. GlobalCastMD Medical Library. 2024-06-07. https://dev.library.globalcastmd.com/article/8711?via_space=staycurrentmd
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