Preoperative topical estrogen application in the management of hypospadias: a systematic review

Topic overview

Key takeaways

• Topical estrogen shows no significant improvement in penile dimensions or reduction in post-urethroplasty complications for hypospadias.
• Four RCTs (387 patients total) used varying estrogen formulations and timing, limiting direct comparison of outcomes.
• Current evidence does not support topical estrogen as superior to conventional testosterone therapy for preoperative hypospadias management.
• Study heterogeneity in formulation, timing, and hypospadias severity requires cautious interpretation of pooled results.
• Further animal and human studies needed to clarify potential wound-healing benefits of estrogen in hypospadias repair.

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