Is neurodevelopment impaired in Brazilian children with intestinal failure on prolonged parenteral nutrition? A single center study

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Key takeaways

• One-third of children with intestinal failure on prolonged parenteral nutrition showed neurodevelopmental delays across cognitive, motor, and language domains.
• Developmental impairment occurred independently of hospitalization length, prematurity, or number of surgical procedures with anesthesia.
• Bayley III assessment identified delays in 34% (cognitive), 33% (motor), and 27% (language) of pediatric IF patients under 42 months.
• Multidisciplinary intestinal rehabilitation programs should incorporate routine neurodevelopmental screening for children on long-term PN.
• Neurodevelopmental monitoring is critical for pediatric IF patients, as approximately one-third demonstrate significant delays despite nutritional support.

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