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MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis

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Topic overview

This study identifies miRNA-192-5p as a protective factor in neonatal necrotizing enterocolitis through its targeting of ALCAM, demonstrating reduced inflammatory markers and intestinal injury in both cell and animal models. The findings suggest miRNA-192-5p modulation as a potential therapeutic approach for NEC management.

Key takeaways

  • MiR-192-5p is downregulated in NEC and its overexpression increases intestinal epithelial cell viability and reduces apoptosis.
  • MiR-192-5p targets ALCAM to suppress inflammatory cytokines IL-1β and IL-6, reducing intestinal inflammatory injury.
  • AgomiR-192-5p treatment in rat NEC models decreased intestinal tissue damage and improved barrier function.
  • The miR-192-5p/ALCAM axis represents a potential therapeutic target for neonatal necrotizing enterocolitis treatment.

Keywords

Necrotizing Enterocolitis Neonatal Gastroenterology Microrna Therapeutics Intestinal Inflammation Epithelial Cell Injury Alcam Pathway

Hashtags

#NeonatalNEC #MicroRNAResearch #IntestinalInflammation #PediatricGastroenterology

Full article text

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How to cite: GlobalCastMD. MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis. GlobalCastMD Medical Library. 2024-05-08. https://dev.library.globalcastmd.com/article/8574?via_space=staycurrentmd

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