Children with Localized Crohn's Disease Benefit from Early Ileocecal Resection and Perioperative Anti-Tumor Necrosis Factor Therapy

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Key takeaways

• Ileocecal resection in pediatric Crohn's disease significantly improves weight z-scores postoperatively, though full normalization is not achieved.
• Perioperative anti-TNF therapy shows promise in reducing postoperative recurrence rates in children undergoing ileocecal resection.
• Early surgical intervention for localized ileocecal Crohn's disease may benefit pediatric patients when combined with biologic therapy.
• Growth parameters (weight, height, BMI z-scores) improve following ileocecal resection regardless of anti-TNF therapy status.
• Postoperative recurrence remains a concern in pediatric Crohn's disease, warranting careful patient selection and perioperative management strategies.

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