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Maternal and Neonatal Outcomes After Ex-Utero Intrapartum Treatment for Congenital Diaphragmatic Hernia: A Case Series

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Topic overview

This case series of 14 patients demonstrates that EXIT procedure for moderate congenital diaphragmatic hernia achieves 85.7% neonatal survival with optimal long-term development and minimal maternal complications. The technique enables controlled airway management during delivery, reducing respiratory failure risk in fetuses with O/E LHR 26-45%.

Key takeaways

  • EXIT procedure achieved 85.7% survival in moderate CDH (O/E LHR 26-45%), significantly better than standard postnatal care requiring ECMO in 75%
  • Maternal safety profile was excellent: 7.1% minor complications, no infections, median hemoglobin drop only 1.9 mg/dL, one transfusion in 14 cases
  • All surviving children showed optimal physical and neurocognitive development with no long-term pulmonary morbidity at follow-up
  • EXIT enables controlled airway management during fetal-neonatal transition, addressing respiratory failure risk in moderate CDH at birth

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How to cite: GlobalCastMD. Maternal and Neonatal Outcomes After Ex-Utero Intrapartum Treatment for Congenital Diaphragmatic Hernia: A Case Series. GlobalCastMD Medical Library. 2023-09-08. https://dev.library.globalcastmd.com/article/8432?via_space=staycurrentmd

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