Evaluation of the protective and therapeutic effects of extra virgin olive oil rich in phenol in experimental model of neonatal necrotizing enterocolitis by clinical disease score, ınflammation, apoptosis, and oxidative stress markers
Topic overview
This experimental study demonstrates that phenol-rich extra virgin olive oil significantly reduces intestinal damage in a neonatal rat model of necrotizing enterocolitis by suppressing inflammation, oxidative stress, and apoptosis. Treatment improved clinical outcomes, reduced inflammatory markers (IL-1β, IL-6), and decreased histopathological injury scores.
Key takeaways
- Phenol-rich extra virgin olive oil significantly reduced clinical disease severity and improved weight gain in experimental neonatal NEC.
- EVOO treatment decreased pro-inflammatory cytokines (IL-1β, IL-6) and oxidative stress markers (MDA) in NEC-induced intestinal injury.
- EVOO reduced intestinal apoptosis (Caspase-3 positive cells) and histopathological damage scores in experimental NEC models.
- High-phenolic EVOO shows promise as both protective and therapeutic intervention for NEC through anti-inflammatory and antioxidant mechanisms.
Keywords
Hashtags
Full article text
Full article text not available for this entry
How to cite: GlobalCastMD. Evaluation of the protective and therapeutic effects of extra virgin olive oil rich in phenol in experimental model of neonatal necrotizing enterocolitis by clinical disease score, ınflammation, apoptosis, and oxidative stress markers. GlobalCastMD Medical Library. 2024-03-17. https://dev.library.globalcastmd.com/article/8403?via_space=staycurrentmd
Comments