Children with Hirschsprung disease exhibited alterations in host–microbial co-metabolism after pull-through operation
Topic overview
This NMR spectroscopy study reveals altered fecal metabolomes in children under 5 following Hirschsprung disease pull-through surgery, with distinct metabolic profiles between those with and without HAEC. Significant decreases in key metabolites and disrupted amino acid metabolism pathways suggest ongoing intestinal dysfunction post-operatively, highlighting potential targets for monitoring and intervention.
Key takeaways
- Post-operative Hirschsprung patients show distinct fecal metabolite profiles compared to healthy children, particularly in amino acid metabolism.
- Children with HAEC after pull-through have significantly lower succinate and xylose levels than those without HAEC complications.
- Acetoin, phenylacetylglutamine, and N-acetylornithine are significantly decreased in all post-pull-through HD patients versus controls.
- Glutamine/glutamate metabolism pathways are significantly altered, suggesting disrupted intestinal integrity and function after surgery.
- NMR spectroscopy of fecal metabolome may help identify biomarkers for HAEC risk stratification in post-operative HD patients.
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How to cite: GlobalCastMD. Children with Hirschsprung disease exhibited alterations in host–microbial co-metabolism after pull-through operation. GlobalCastMD Medical Library. 2024-03-21. https://dev.library.globalcastmd.com/article/8396?via_space=staycurrentmd
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