Evaluation of the Molecular Landscape of Pediatric Thyroid Nodules and Use of a Multigene Genomic Classifier in Children

Study validates multigene genomic classifier for pediatric thyroid nodules, demonstrating 96% sensitivity and 78% specificity in distinguishing benign from malignant lesions. Pediatric thyroid cancers show unique molecular profile dominated by RET/NTRK fusions rather than BRAF/RAS mutations typical in adults, suggesting molecular testing could reduce unnecessary diagnostic surgeries in children.