Development of a porcine acellular bladder matrix for tissue-engineered bladder reconstruction

Researchers developed a porcine-derived acellular bladder matrix using dynamic detergent-enzymatic decellularization as an alternative to enterocystoplasty for bladder augmentation. The resulting scaffold preserved extracellular architecture, demonstrated enhanced biomechanical properties and angiogenic potential, and maintained urodynamic compliance, suggesting promise for tissue-engineered bladder reconstruction in clinical applications.