What Every Pediatric Surgeon Should Know About Common Systemic Therapies for the Treatment of Renal Tumors in Children and Adolescents

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Key takeaways

• Renal tumors rank among the most common solid malignancies in pediatric patients requiring multidisciplinary treatment approaches.
• Surgery remains the primary treatment modality, supplemented by chemotherapy and radiation based on tumor risk stratification.
• Timing between surgery and chemotherapy is critical—surgeons must understand how systemic agents affect perioperative management.
• Familiarity with common chemotherapeutic agents and targeted therapies is essential for optimizing surgical timing and outcomes.
• Risk-adapted treatment protocols guide the selection and sequencing of chemotherapy, radiation, and surgical intervention.

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